Natural product therapy for pulmonary arterial hypertension




A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

This study suggests, for the first time, Hibiscus extract, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “Hibiscus extract or an active compound isolated from it” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: org or

To cite: Boominathan, Natural product therapy for Pulmonary Fibrosis: Berberine increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down regulation of its target gene, 7/October/2015, 11.06 pm, Genome-2-Bio-Medicine Discovery center (GBMD),



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