Newbioideas

Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3


AMOUNT: $ 200

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

Significance:

Thymoquinone, by increasing the expression of its target gene, it may decrease the expression of Notch3. Thus, pharmacological formulations encompassing “Thymoquinone or its analogues” may be used to treat pulmonary arterial hypertension.

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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Undisclosed information: How Thymoquinone decreases the expression of Notch3

Amount:$200#

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Citation: Boominathan, Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 1/October/2016, 11.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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