Newbioideas

Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene


AMOUNT: $ 300

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was published in the 28 September 2016 issue of Nature by Prof Michael A.White, Kim, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene

Significance:

Given that: (1) 20-30% of people with lung cancer have mutations in k-ras gene; (2) out of 1.82 million people diagnosed with lung cancer in 2012, 1.56 million people died; (3) most of the k-ras mutation-containing lung tumors are not amenable to radiation therapy; (4) there are no effective anti-ras therapy available at present; (5) lung cancer is one of the most frequent cancer in men; (6) lung cancer is more common in developed countries than in developing countries; and (7) the global economic cost spent for lung cancer treatment is enormous, there is an urgent need to find: (a) a newer and effective treatment for K-ras mutated lung cancers; (b) a cheaper alternative to the existing expensive non-specific drugs; and (c) a Natural product-based side-effect-free drug.

Prof. Michael A. White’s research team has recently shown that inhibition of XPO expression in lung cancer inhibits the progression of K-ras mutated lung cancer through down regulation of NFKB transcriptional activity.

On the foundation of this interesting finding, this study suggests a Natural product-based anti-cancer therapy for K-ras mutated human cancers. Thymoquinone, by increasing the expression of its target gene, it may decrease the expression of XPO1.

Thereby, it may: (1) increase the levels of NFKBIA, (2) inhibit NFKB transcriptional activity; and (3) suppress the progression of KRAS-mutant lung cancer. Thus, by treating lung cancer patients with Thymoquinone, one may prevent the progression of Kras-mediated lung cancer.

Together, this study suggests that pharmacological formulations encompassing “Thymoquinone or its analogue” may be used to inhibit the progression of Kras-mediated lung cancer.

Thymoquinone or its analogue may

Thymoquinone or its analogue may inhibit the progression of K-ras mutated lung cancers via down regulation of XPO1

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: http://genomediscovery.org  newbioideas.com

Citation: Boominathan, Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 03/October/2016, 10.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation

Undisclosed information: How Thymoquinone decreases the expression of XPO1

Amount: $300#

Results guaranteed if not refunded

REGISTER

   

Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

Add comment

Most popular