A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March 2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.
This study suggests, for the first time, a Natural product-based cardiac rejuvenation therapy.
This study suggests, for the first time, that Fenugreek seed extract, by increasing the expression of its target gene, it may suppress the expression of tumor suppressor p16(INK4a). Thereby, it may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility. Thus, by treating myocardial patients with Fenugreek seed extract, one may prevent Dilated cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function. Thus, pharmacological formulations encompassing “Thermostable extract of fenugreek seeds or an active compound isolated from it” may be used to inhibit dilated cardiomyopathy and heart failure.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 28/September/2016, 10.12 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Fenugreek seed extract suppresses the expression of tumor suppressor p16(INK4a).