Newbioideas

Natural product-based therapy for p53-mutated human cancers: Ursolic acid increases the expression of tumor suppressor p53 homologue TAp63 via down regulation of its target gene


AMOUNT: $ 200

Idea Proposed/Formulated by:Dr L Boominathan Ph.D.

Terms & Conditionsapplyhttp://genomediscovery.org/registration/terms-and-conditions/

Citation:Boominathan, Natural product-based therapy for p53-mutated human cancers: Ursolic acid increases the expression of tumor suppressor p53 homologue TAp63 via down regulation of its target gene, 4/March/2015, 8.31 am,Genome-2-Bio-MedicineDiscovery center(GBMD),http://genomediscovery.org

Significance:This study suggests, for the first time, that Ursolic acid,by decreasing the expression of its target gene,it may increase the expression of TAp63. Thereby, it may inhibit cancer progression.Thus,pharmacological formulationsencompassing“Ursolic acid or its analogues” can be used to inhibit the progression of human tumors.

Amount: $ 300*

Undisclosed information:How Ursolic acidincreases the expression ofTAp63

Web:http://genomediscovery.org

Courtesy:When you cite drop us a line atinfo@genomediscovery.org

* Research cooperation

 

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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