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Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene


AMOUNT: $ 300

A study from the Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain“ shows that: “Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.” This study was published in the 14 July 2015 issue of the journal “Cell Reports” by Prof. Maria, Povedano JM and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

Significance:

Given that: (1) Idiopathic pulmonary disease (IPD)/Idiopathic pulmonary fibrosis (IPF) is a progressive degenerative disease of the lung, with debilitating consequences; (2) drugs that are currently used to treat IPF are ineffective; and (3) 6.8-16.3 per 100,000 persons suffer from Idiopathic pulmonary disease, there is an urgent need to find: (i) a way to induce regeneration of lung cells in Idiopathic pulmonary fibrosis patients; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and cure IPF.

A number of studies suggest that genes that promote telomere protection are mutated in Idiopathic pulmonary fibrosis. Prof. Maria’s research team has recently shown that deletion of telomeric repeat binding factor (TRF1) promotes pulmonary fibrosis.

I have published earlier that Resveratrol increases the expression of TRF1 (Boominathan, From improving telomere function to increasing genome integrity: Resveratrol, a longevity promoting small molecule, increases the expression of TRF1 via downregulation of its target miRNA, 1/June/2014, 7.14).

Resveratrol
Figure1: Resveratrol, found abundantly in the skin of grapes (50 to100/gram) ameliorates pulmonary fibrosis via upregulation of TRF1

This study suggests, for the first time, that Resveratrol, by increasing the expression of its target gene, it may increase the expression of TRF1. Thereby, it may: (1) alleviate DNA damage; (2) ameliorate telomere dysfunction and promote telomere function and integrity; (3) inhibit the development and progression of pulmonary fibrosis.

Thus, pharmacological formulations encompassing “Resveratrol or its analogues may be used to treat Idiopathic pulmonary fibrosis.

Undisclosed information: How Resveratrol increases the expression of TRF1.

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To cite: Boominathan, Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene, 8/October/2015, 4.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Attention: Kindly understand that this idea was posted earlier by us, but then we lost it on our website because somebody had hacked our website in the second week of Oct, 2015. We are in the process of recovering our ideas posted earlier, especially from May, 2015 to October, 2015. So, this idea is re-posted for the sake of the researche

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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