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Natural product-based Life-span extension therapy: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene


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A recent study from theInstitute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UKshows that“Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.”This study was published in the 2 October2009 issue of the Journal“Science” (I.F: 31.477)byProfDominic J. Withers, Dr.Selman Cand others.

On the foundation of this interesting finding,Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD,reports that:Natural product-based Life-span extension therapy: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene.

Idea Proposed/Formulated by:Dr L Boominathan Ph.D.

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Citation:Boominathan, Natural product-based Life-span extension therapy: Agaricus blazei Murill (AbM),a medicinal mushroom,inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene, 17/March/2015, 10.09 am,Genome-2-Bio-MedicineDiscovery center(GBMD),http://genomediscovery.org

Web:http://genomediscovery.org

Courtesy:When you cite drop us a line atinfo@genomediscovery.org

Significance:This study suggests that tumor suppressor Agaricus blazei Murill (AbM),by increasing the expression of its target gene, it may decreasethe expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase).Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity.Thus,pharmacological formulationsencompassing“Agaricus blazei Murill or bio-chemical components derived from AbMmay be used toincrease the life span of an individual.

Undisclosed information: HowAgaricus blazei Murill (AbM) decreases the expression ofp70S6 Kinase

 

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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