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Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinking inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene


AMOUNT: $ 300

A recent study from theInstitute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germanyshows that“MicroRNA-34a regulatescardiacageingand function.”This study was published in the March7 2013NaturebyProf Dimmler, Boon,and others.

On the foundation of this interesting finding,Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD,reports that: Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinkinginhibits myocardial function and promotes myocardial infarction via up regulation of its targetgene.By limiting the intake of alcohol,one may prevent ageing/stress-associated decline in cardiac function.Together, this studysuggests thatpharmacological formulations encompassing“compounds that inhibit Alcohol-induced target genes”may be used to improve cardiac function in heavy drinkers.

Idea Proposed/Formulated by:Dr L Boominathan Ph.D.

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Citation:Boominathan,Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinkinginhibits myocardial function and promotes myocardial infarction via up regulation of its targetgene,23August/2014, 05.44 am,Genome-2-Bio-MedicineDiscovery center(GBMD),http://genomediscovery.org

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Significance:This study elucidates the mechanism by which Alcohol declines myocardial function. Furthermore, this study suggests, for the first time, small molecule compounds that inhibit Alcohol-induced target gene expression may be used to treat alcoholics suffering from various myocardial disorders, including myocardial infarction.

 

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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