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Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene


AMOUNT: $ 300

A study from the Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain“ shows that: “Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.” This study was published in the 14 July 2015 issue of the journal “Cell Reports” by Prof. Maria, Povedano JM and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

Significance:

Given that: (1) Idiopathic pulmonary disease (IPD)/Idiopathic pulmonary fibrosis (IPF) is a progressive degenerative disease of the lung, with debilitating consequences; (2) drugs that are currently used to treat IPF are ineffective; and (3) 6.8-16.3 per 100,000 persons suffer from Idiopathic pulmonary disease, there is an urgent need to find: (i) a way to induce regeneration of lung cells in Idiopathic pulmonary fibrosis patients; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and cure IPF.

A number of studies suggest that genes that promote telomere protection are mutated in Idiopathic pulmonary fibrosis. Prof. Maria’s research team has recently shown that deletion of telomeric repeat binding factor (TRF1) promotes pulmonary fibrosis.

This study suggests, for the first time, that nitric oxide, by decreasing the expression of its target gene, it may increase the expression of TRF1. Thereby, it may: (1) alleviate DNA damage; (2) ameliorate telomere dysfunction and promote telomere function and integrity; (3) inhibit the development and progression of pulmonary fibrosis. Thus, pharmacological formulations encompassing “Nitric oxide“ may be used to treat Idiopathic pulmonary fibrosis.

Substances that aid in the production of nitric oxide naturally are: arugula, lettuce, kale, watercress, pepper, tofu, dark chocolate and supplements containing L-Citrulline and L-arginine.

Undisclosed information: How nitric oxide increases the expression of TRF1.

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To cite: Boominathan, Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene, 8/October/2015, 4.54 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Attention: Kindly understand that this idea was posted earlier by us, but then we lost it on our website because somebody had hacked our website in the second week of Oct, 2015. We are in the process of recovering our ideas posted earlier, especially from May, 2015 to October, 2015. So, this idea is re-posted for the sake of the researchers

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Dr.Boominathan PhD

Dr Boominathan was the first one in the world to propose a p73/p63-dependent cancer suppressor pathway (Supported by a legally valid Invention disclosure document certified by an advocate-2002/3)

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