Author - Dr.Boominathan PhD

Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinking inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene

Natural product-based Life-span extension therapy: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene

Natural product-based Anti-ageing therapy: Kaempherol, found in leeks, apples, and onions, increases the expression of immortality gene telomerase via down regulation of its target genes

Natural product-based therapy for p53-mutated human cancers: Ursolic acid increases the expression of tumor suppressor p53 homologue TAp63 via down regulation of its target gene

TUMOR SUPPRESSOR GENES

Natural product-based therapy for tumorsuppression: Berberine suppresses & increases the expression of DNp63? & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene

CANCER/CANCER STEM CELLS

Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene

Insights into the treatment of pulmonary arterial hypertension: Epigallocatechin gallate (EGCG), the main component of green tea, decreases pulmonary arterial hypertension via down regulation of its target gene

Treating Diabetes Mellitus with an arthritis drug: Withaferin A (WFA) promotes �-cell mass and function via down regulation of its target gene

CANCER/CANCER STEM CELLS

Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene

RESPIRATORY ILLNESS

Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene