Newbioideas – Newbioideas

YOUR FUNDING WILL AID FINDING CURE FOR HUMAN DISEASES

VISION STATEMENT

An ideal vision of Bio-medical research is to create a Disease-free Earth. The Genome-2-Bio-Medicine Discovery (GBMD) Center aims to play its part in creating one by providing (i) Bio-Medical/Pharma/Therapeutic/Clinical Ideas; & (ii) Disease- curing/treating solutions to Scientists/Physicians/Researchers/Medical Professionals.An ideal vision of Bio-medical research is to create a Disease-free Earth.

MYOCARDIALDISORDERS

Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene

A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence...

Dr.Boominathan PhD

MYOCARDIALDISORDERS

Molecular therapy for Myocardial Infarction: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)

Dr.Boominathan PhD

MYOCARDIALDISORDERS

Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi [OcimumSanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene

A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence...

Dr.Boominathan PhD

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MYOCARDIALDISORDERS

Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7...

Dr.Boominathan PhD

CANCER/CANCER STEM CELLS

Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene

CANCER/CANCER STEM CELLS

Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene

CANCER/CANCER STEM CELLS

Natural product therapy targeting aberrant Lipid synthesis in Human cancers: 8-hydrocalamenene, derived from Reynoutria elliptica, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene

CANCER/CANCER STEM CELLS

Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene

CANCER/CANCER STEM CELLS

Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene

CANCER/CANCER STEM CELLS

Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Agaricus blazei Murill (AbM) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene

HYPERTENSION

Insights into the treatment of pulmonary arterial hypertension: Epigallocatechin gallate (EGCG), the main component of green tea, decreases pulmonary arterial hypertension via down regulation of its target gene

Idea Proposed/Formulated by:Dr L Boominathan Ph.D. Web: Terms & Conditionsapplyhttp://genomediscovery.org/registration/terms-and-conditions/ To cite:Boominathan, Insights into the treatment of pulmonary arterial...

Dr.Boominathan PhD

HYPERTENSION

Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of...

Dr.Boominathan PhD

RESPIRATORY ILLNESS

Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

RESPIRATORY ILLNESS

Natural product therapy for Pulmonary Fibrosis: Berberine increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down regulation of its target gene

RESPIRATORY ILLNESS

Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

RESPIRATORY ILLNESS

Natural product therapy for Pulmonary Fibrosis: Onion Peel extract (OPE) increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down regulation of its target gene

RESPIRATORY ILLNESS

Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): Tumor suppressor ARF increases Cilia length and number via up regulation of its target gene

RESPIRATORY ILLNESS

Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): E2F1 increases Cilia length and number via up regulation of its target gene

Natural product therapy for pulmonary arterial hypertension: Scutellaria baicalensis inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

Natural product therapy for pulmonary arterial hypertension: γ-Bisabolene, one of the main components in Cardamom, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

YOUR FUNDING WILL AID FINDING CURE FOR HUMAN DISEASES

VISION STATEMENT

MYOCARDIALDISORDERS

Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene

Molecular therapy for Myocardial Infarction: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)

Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi [OcimumSanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene

Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)

CANCER/CANCER STEM CELLS

Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene

HYPERTENSION

Insights into the treatment of pulmonary arterial hypertension: Epigallocatechin gallate (EGCG), the main component of green tea, decreases pulmonary arterial hypertension via down regulation of its target gene

Natural product therapy for pulmonary arterial hypertension: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

RESPIRATORY ILLNESS

Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene

Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): Tumor suppressor ARF increases Cilia length and number via up regulation of its target gene

Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): E2F1 increases Cilia length and number via up regulation of its target gene

BONE-RELATED DISORDERS

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