YOUR FUNDING WILL AID FINDING CURE FOR HUMAN DISEASES

Vision Statement

An ideal vision of Bio-medical research is to create a Disease-free Earth. The Genome-2-Bio-Medicine Discovery (GBMD) Center aims to play its part in creating one by providing (i) Bio-Medical/Pharma/Therapeutic/Clinical Ideas; & (ii) Disease- curing/treating solutions to Scientists/Physicians/Researchers/Medical Professionals.

Recent Ideas

Myocardialdisorders

Small RNA-based therapy for Myocardial Infarction: p53 homolouge, p63 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 15/September/2014, 06.54 am

NIDDM/IDDM

Natural product-based therapy for Diabetes mellitus: ?-tocotrienol, a derivative of vitamin-E, increases islet insulin levels, islet cell mass and glucose tolerance via down regulation of NMDA receptor GluN2A, 7/October/2015, 11.08 pm

hypertension

Insights into the treatment of pulmonary arterial hypertension: Epigallocatechin gallate (EGCG), the main component of green tea, decreases pulmonary arterial hypertension via down regulation of its target gene, 15/April/2014, 9.18 am

Cancer/Cancer Stem cells

Vitamins-based therapy for Metastatic Pancreatic/intestine/ovarian Cancer: ?-tocotrienol (a derivative of Vitamin-E) suppresses the expression of PDGF Receptor ? via up regulation of its target gene., 16/July/2014, 6.36 am

Tumor suppressor genes

Natural product-based therapy for tumorsuppression: Berberine suppresses & increases the expression of DNp63? & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/March/2015, 08.03 am

p53/p63/p73

Natural product-based therapy for p53-mutated human cancers: Ursolic acid increases the expression of tumor suppressor p53 homologue TAp63 via down regulation of its target gene, 4/March/2015, 8.31 am

Neurodegenerative Disorders

Neutralizing Neurotoxic miRNA to protect the brain from neurodegenerative diseases, multiple sclerosis and stroke : The reprogramming and stem cell gene Lin-28 prevents neurotoxicity via down regulation of its target gene, 12/June/2014, 9.09 am

Respiratory Illness

Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): E2F1 increases Cilia length and number via up regulation of its target gene, 7/June/2014, 6.40 am

Ageing

Natural product-based Anti-ageing therapy: Kaempherol, found in leeks, apples, and onions, increases the expression of immortality gene telomerase via down regulation of its target genes, 13/June/2015, 11.36 pm

Longevity

Natural product-based Life-span extension therapy: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene, 17/March/2015, 10.09 am

Regenerative Medicine

Interleukin-based regenerative therapy for Injured tissues: IL-17 promotes epithelial regeneration and tissue growth via downregulation of its target gene, 10/March/2015, 8.43 am

Infectious Diseases

Vitamin-based Immune enhancement therapy: ATRA (A derivative of Vitamin-A) increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 07/3/2015, 16.23

Genome Medicine

SIRT6 and p53 cooperate with each other in tumor suppression, metabolic disease and ageing 30/Jun/2012

Learning, Memory & Cognition

Therapeutic Insights into Stress-induced impairment of Cognition and Memory: Stress responsive protein p53 suppresses the expression of GlcNAc N-deacetylase/N-sulfotransferase-1 via up regulation of its target gene, 29/August/2014, 09.45 am

Alcoholism

Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinking inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene, 23August/2014, 05.44 am

Bone-related disorders

Natural product therapy for Bone disorders: Honokiol, found in the cones, bark, and leaves of Magnolia grandiflora, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 22/September/2016, 3.02 pm

Skin-related disorders

Natural product-based therapy for Psoriasis: Curcumin, the major compoent of turmeric, decreases psoriasiform skin inflammation via down regulation of its target gene, 01/October/2014, 06.06 am

General medicine/biology

Natural product-based therapy for Myopathy: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, induces autophagy, maintains blood sugar during fasting, decreases aging-associated myopathy and mitochondrial dysfunction via up regulation of its target gene, 11/June/2015, 10.26 am

Our finding will aid finding cure for human diseases

Bio-Therapetic/Medical/Pharma Ideas
    Total Number of Ideas:7871
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Id:45666
Natural product therapy for Pulmonary Fibrosis: Berberine increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down regulation of its target gene, 7/October/2015, 11.06 pm
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2016-10-16
$:300
Id:45667
Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Agaricus blazei Murill (AbM) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 7/october/2016, 11.23 pm
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2016-10-16
$:300
Id:45668
Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Litchi (Litchi chinensis) flower extract suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene, 7/October/2016, 11.53 pm
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2016-10-16
$:300
Id:45669
Natural product therapy for Pulmonary Fibrosis: Pear water extract increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down-regulation of its target gene, 8/October/2015, 3.46 pm
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2016-10-16
$:300
Id:45670
Natural product-based therapy for Idiopathic pulmonary fibrosis: Resveratrol, a longevity promoting small molecule found in grapes and ground nuts, increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene, 8/October/2015, 4.24 pm
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2016-10-16
$:300
Id:45671
Gaseous therapy for Idiopathic pulmonary fibrosis: Nitric oxide increases TRF1 expression and ameliorates pulmonary fibrosis via upregulation of its target gene, 8/October/2015, 4.54 pm
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2016-10-16
$:300
Id:45672
Natural product Life-extension therapy: Ampelopsin (AMP), a flavonol mainly found in Ampelopsis grossedentata, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 8/October/2016, 5.24 pm
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2016-10-16
$:300
Id:45673
Natural product therapy targeting aberrant Lipid synthesis in Human cancers: 8-hydrocalamenene, derived from Reynoutria elliptica, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene, 8/October/2016, 11.07 pm
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2016-10-16
$:300
Id:45662
Life-extension therapy: 3,6-dihydroxyflavone (3,6-DHF) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 6/October/2016, 7.19 am
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2016-10-12
$:100
Id:45663
Natural product Life-extension therapy: Neem leaf extract inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target genes, 6/October/2016, 8.40 am
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2016-10-12
$:300
Id:45664
Natural product therapy for Pulmonary Fibrosis: Onion Peel extract (OPE) increases Toll-like receptor 4 expression and extracellular matrix glycosaminoglycan Hyaluronan levels, promotes alveolar progenitor cell renewal and repair of lung injury and prevents severe pulmonary fibrosis via down regulation of its target gene, 6/October/2015, 1.24 pm
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2016-10-12
$:500
Id:45665
Natural product cancer therapy: Neem leaf extract inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1 via up-regulation of its target gene, 6/October/2016, 2.29 pm,
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2016-10-12
$:300
Id:45659
Molecular therapy for Myocardial Infarction: JunB improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 5/October/2016, 7.38 am
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2016-10-06
$:300
Id:45660
Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-497 increases the expression of tumor suppressor p53 homologue TAp63γ and induces regression of p53-mutated human tumors via down regulation of its target gene, 5/October/2016, 8.14 am
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2016-10-06
$:300
Id:45661
Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 5/October/2016, 10.00 am
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2016-10-06
$:100
Id:45657
Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 04/October/2016, 7.57 am
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2016-10-04
$:200
Id:45658
Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene, 4/October/2016, 10.35 pm
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2016-10-04
$:500
Id:45654
Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 03/October/2016, 10.59 am
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2016-10-03
$:300
Id:45656
Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Ursolic acid, one of the main components of Tulsi and apple peels, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene, 3/October/2016, 11.37 am
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2016-10-03
$:500
Id:45649
Natural product Immune enhancement therapy: Hibiscus extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 1/October/2016, 10.03 am
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2016-10-02
$:200

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